The latest Japanese Clinical study demonstrates NMN’s insulin-promoting effects. 

A study conducted by Uchiyama and colleagues from Osaka University in Japan investigated the effects of NMN supplementation on insulin levels and NAD+ levels in healthy adults. Eleven participants were given a daily dose of 250mg of NMN for a duration of 12 weeks. The results showed that after two months of supplementation, there was a significant fivefold increase in blood serum insulin levels. Additionally, the study demonstrated that NMN supplementation led to a substantial elevation of blood plasma NAD+ levels after the first month, although these levels gradually decreased over the following two months of continued NMN usage. 

This study also revealed a novel finding: 

NMNN supplementation increased NMN levels specifically in the blood plasma, which is the liquid component of blood without the presence of cells. This suggests that NMN is distributed throughout the body via circulation, reaching various cells and tissues. The findings confirmed that NMN supplementation effectively increased NAD+ levels and indicated that NMN supplementation can elevate insulin levels, a marker of metabolic he alth. Insulin is vital for utilizing glucose for energy in the body.  

Uchiyama and colleagues conducted a study to investigate the effects of NMN on human metabolism, particularly focusing on insulin levels. They measured insulin levels in blood serum, which is blood plasma with clotting factors removed. Initially, the average blood insulin concentration was 6.95 U/mL. After two months of NMN supplementation, there was a significant fivefold increase in insulin levels, with a concentration of 39.2 U/mL. By the third month of NMN supplementation, insulin levels tapered off but remained elevated at 28.1 U/mL. 

It’s important to note that insulin levels were measured after lunch, as blood glucose levels tend to rise after eating, triggering higher insulin production. The study’s results indicate that NMN supplementation for two months can increase insulin levels after meals, aiding the body in utilizing glucose for energy. These findings show that NMN supplementation has a positive impact on insulin regulation and glucose metabolism. 

In line with previous studies examining the effects of NMN on humans, the research group from Japan aimed to investigate the impact of NMN on NAD+ levels. They measured blood plasma NAD+ levels at one, two and three months of NMN supplementation, as well as one month after discontinuing NMN intake. The results showed that NMN supplementation led to a remarkable increase in NAD+ levels, with an average over fivefold rise after one month. However, the subsequent two and three months of NMN usage showed a tapering off of NAD+ levels. Notably, in the NAD+ concentrations measured at one, two and three months of NMN supplementation, NAD+ levels dropped and returned to near their initial concentrations


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