The Science Behind Spermidine

Learn how supplementing with Spermidine can support cellular rejuvenation, cardiovascular health, and healthy aging.

What is Spermidine?

Spermidine is a polyamine that exists naturally in all living organisms. Essential cellular functions are supported by spermidine, including the preservation of DNA stability, the transcription of DNA into RNA, and the prevention of cellular apoptosis or programmed cell death. As we age, spermidine levels tend to decline, contributing to the emergence of age-associated conditions.

Spermidine, alongside putrescine, possesses a remarkable ability: the promotion of autophagy—a cellular process that breaks down and recycles damaged or unwanted components, acting as a quality control process for mitochondria. Preventing the build-up of toxic proteins and other substances can target the root cause of age-related diseases, particularly Alzheimer's and Parkinson’s.

While typical dietary supplements aim to fill nutritional gaps missing from our diets, anti-aging supplements with spermidine contain active ingredients to target specific pathways in the body to slow down the aging process.

Promote Longevity

Boost cellular health and longevity by supplementing with spermidine. It achieves this by mimicking the antiaging benefits associated with fasting through the process of autophagy.

Support Brain Health

Improve cognitive function with a spermidine supplement. Spermidine can potentially protect neurons against damage from oxidative stress, inflammation, and ischemia (lack of blood flow).

Improve Skin Health

Promote more youthful-looking skin and a vibrant complexion with spermidine. Spermidine may target signs of aging by supporting cellular renewal and maintaining the integrity of skin cells.

Is Spermidine Safe?

Yes! Spermidine is generally considered safe since it's a naturally occurring compound in the body and is present in our regular diet. It is found in many common foods, such as fruits, vegetables, and grains. Dietary sources of spermidine include wheat germ, soybeans, mushrooms, and aged cheeses, such as cheddar and blue cheese. Here are reasons why spermidine is safe:

  1. Data suggests that using a spermidine supplement is safe, well tolerated, and has no adverse side effects.
  2. Toxicological studies show spermidine has low toxicity levels, even at relatively high doses
  3. Reputable supplement brands adhere to quality standards and undergo third-party testing of spermidine to ensure safety.

Individual responses to spermidine can vary. Always consult a healthcare professional before starting a new supplement.

Spermidine Supports the 9 Hallmarks of Aging

Combining spermidine in an NMN supplement will produce a synergistic effect to target all 9 hallmarks of aging. NMN is the base of our Rejuve+™ NMN21000 health product, along with NMN, PQQ, and Pterostilbene

  • Genomic Instability: support DNA stability and repair processes
  • Telomere Attrition: preserve telomere length and integrity
  • Epigenetic Alterations: autophagy can influence epigenetic changes
  • Loss of Proteostasis: help remove damaged proteins
  • Deregulated Nutrient Sensing: cellular metabolism and nutrient balance
  • Mitochondrial Dysfunction: antioxidative properties to support mitochondria
  • Cellular Senescence: removal of senescent cells, promoting tissue health
  • Stem Cell Exhaustion: maintain functional stem cells
  • Altered Intercellular Communication: restore communication between cells

Spermidine for DNA Replication

Spermidine is a naturally occurring polyamine compound that is found in all living cells, from bacteria to humans. It is an important component that plays a crucial role in a variety of cellular processes. One of the main functions of spermidine is its involvement in DNA replication, transcription, and translation. During DNA replication, spermidine helps to stabilize the DNA double helix structure, which is important for the accurate copying of genetic material. 

Spermidine is also involved in the transcription process, which is the first step in gene expression, by helping to unwind and stabilize the DNA molecule. Finally, during translation, spermidine is involved in the formation of ribosomes, which are molecular machines responsible for the synthesis of proteins from RNA.

Anti-Aging Effects With Spermidine

Spermidine, a naturally occurring polyamine compound, has been found to have anti-aging effects in various model organisms. Studies have shown that supplementation with spermidine can enhance cellular processes that promote longevity and protect against age-related diseases. One of the ways that spermidine promotes longevity is by inducing autophagy, a cellular process in which damaged or dysfunctional cellular components are broken down and recycled. 

Autophagy is important for maintaining cellular homeostasis and preventing the accumulation of damaged molecules that can contribute to aging and age-related diseases. Studies have shown that spermidine can induce autophagy in various cell types, including liver, heart, and brain cells, and in various model organisms, yeast, worms, and mice.

Spermidine For Protection Against Diseases

Spermidine has been found to have neuroprotective properties and can help to reduce the risk of these diseases by reducing oxidative stress and inflammation in the brain. Spermidine benefits also include anti-inflammatory properties, which can help to reduce chronic inflammation in the brain that can contribute to the development of neurodegenerative diseases. 

Its ability to induce autophagy, a process that clears out damaged cellular components and recycles materials is promising for preventing the buildup of harmful components that contribute to diseases like Alzheimer's, Parkinson's, and cardiovascular conditions. Spermidine has been found to reduce inflammation in brain cells and protect against inflammation-induced damage.

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