Learn how supplementing with Pyrroloquinoline Quinone (PQQ) can support cellular function and promote brain function.
What is PQQ?
Pyrroloquinoline quinone (PQQ) is a natural compound that already exists within our cells and currently gaining attention for its potential cellular production benefits. PQQ is a redox cofactor, which means that it can accept or donate electrons during chemical reactions. While its precise role in the human body is not completely understood, PQQ is known for its potent antioxidant properties. Antioxidants, known as “free radical scavengers", protect cells, proteins, and DNA from damage caused by free radicals. Free radicals are unstable molecules that can damage cells and contribute to the development of various diseases.
Incorporating a PQQ supplement may increase mitochondria function, which are the energy-producing structures within cells. Mitochondria are the "powerhouses" of cells that generate the majority of ATP (adenosine triphosphate) that cells need to function effectively. By activating a crucial transcription factor protein known as CREB (cAMP response element-binding protein), PQQ triggers a cascade of events that stimulate the growth and replication of new mitochondria to meet energy demands.
Certain foods, such as vegetables, fruits, and some animal products can have PQQ. However, supplementation with PQQ is more efficient and is often a vital ingredient included in health products to support energy, cognitive function, and longevity.
Is PQQ Safe?
Pyrroloquinoline quinone (PQQ) is generally considered safe when used properly. Research and studies have not indicated any adverse PQQ supplement side effects within the recommended daily dosage of 10 mg to 20 mg. Here are reasons why PQQ is safe:
- PQQ is a natural compound found in our bodies and some foods, including green peppers, parsley, spinach, green tea kiwi fruit, and papaya.
- Pyrroloquinoline quinone does not appear to have any significant toxic side effects in participants of clinical trials and studies.
- PQQ supplement products often undergo third-party testing to ensure they adhere to safety and quality standards.
As with any anti aging supplement, follow the recommended dosages, choose a reputable supplement brand, and consult with a healthcare professional to take into account your body weight, dietary preferences, existing health conditions, and potential interactions with other medications.
PQQ Supports the 9 Hallmarks of Aging
Combining PQQ in an NMN supplement will produce a synergistic effect to target all 9 hallmarks of aging. NMN is the base of our Rejuve+™ NMN21000 health product, along with PQQ, Spermidine, and Pterostilbene.
- Genomic Instability: reduce damage and mutations to DNA
- Telomere Attrition: reduce telomere shortening for optimal cell division
- Epigenetic Alterations: may prevent changes to gene activity
- Loss of Proteostasis: reduce build up of damaged or misfolded protein
- Deregulated Nutrient Sensing: help cells sense the amount of nutrients present
- Mitochondrial Dysfunction: increase efficiency and energy production
- Cellular Senescence: prevent cells from entering a ‘zombie’ state
- Stem Cell Exhaustion: increase regenerative capacity in stem cells
Altered Intercellular Communication: decrease disrupted signal between cells
Pyrroloquinoline quinone (PQQ) is an antioxidant due to its ability to scavenge free radicals and reduce oxidative stress. Free radicals are unstable molecules that can damage cells and DNA, leading to inflammation and a variety of health problems. PQQ can help neutralize free radicals by donating electrons to stabilize them, which can help prevent oxidative damage.
Pyrroloquinoline quinone has also been shown to increase the activity of antioxidant enzymes such as superoxide dismutase (SOD) and catalase, which are responsible for breaking down harmful reactive oxygen species (ROS) and reducing oxidative stress. PQQ can help to regenerate other antioxidants such as vitamin C and vitamin E, enhancing their effectiveness in protecting against oxidative damage.
Pyrroloquinoline quinone (PQQ) has been shown to have enormous benefits for brain health. PQQ can help to support the growth and survival of neurons, which are the cells responsible for transmitting information in the brain. PQQ has also been shown to enhance mitochondrial function in the brain, which is critical for maintaining energy production and overall brain health.
Research has suggested that PQQ may have neuroprotective effects. It helps to reduce oxidative stress and inflammation, which can contribute to age-related cognitive decline and neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. PQQ has been proven to enhance the production of nerve growth factor (NGF), which is a protein that helps to promote the growth and survival of neurons. By increasing NGF production, PQQ helps to support cognitive function, memory, and learning ability.
Pyrroloquinoline quinone (PQQ) has been shown to have potential benefits for the immune system. PQQ can help to support the growth and activity of the immune cells, which are responsible for fighting off infections and other threats to the body. Research has it that PQQ can enhance the production and activity of white blood cells, which are the cells of the immune system responsible for detecting and eliminating foreign invaders such as bacteria and viruses. PQQ can also help to support the duction of natural killer (NK) cells, which are specialized immune cells that can identify and destroy cancerous or infected cells.