The elevation of NAD+ levels can be achieved by NMN, a nucleotide derived from ribose and nicotinamide. NMN is produced naturally in all living organisms and is a direct precursor to NAD+. Its supplementation can lead to increased NAD+ levels, which can rejuvenate cells and promote repair of cellular damage.
NAD+ is a vital coenzyme required for numerous cellular functions, including metabolic processes such as glycolysis, the Krebs Cycle, and the electron transport chain. As we age, we accumulate DNA damage caused by environmental factors and poor lifestyle choices. The decline of NAD+ levels makes it difficult for repair proteins like PARP to fix DNA damage, which could ultimately cause the onset of age-related diseases.
Fasting and calorie restriction can boost NAD+ levels, but taking supplements like NMN is more effective. However, taking NAD+ directly as a supplement is not practical because it cannot easily penetrate cell membranes. Instead, precursor molecules such as NMN are more efficient in raising NAD+ levels. Studies on animals and humans have shown that NMN is safe to use even in long-term doses of up to 500mg per day.
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